For a long time I did not like when people declare their ports like this in VHDL:

entity example is
  port (
    foo    : in        std_logic;
    bar    : out     std_logic;
    glarp : inout std_logic
  );

I was fine with vertical alignment along the colons, but the additional whitespace after the in/out keywords just looked horrific to me.
The same goes, to a less extent, for Verilog multibit wires/registers:

module example (
  input  wire [7:0] foo,
  output reg        bar
)

This all changed when I found out about column mode editing in Notepad++.