On my new Windows 10 installation I came across a few more issues:

LibreOffice did have a nasty offset where the mouse pointer would click way above where it was pointing. The solutions to this bug was to disable OpenGL rendering as described here.

Another bad experience was with VirtualBox which would sometimes boot up virtual machines with corrupted graphics where nothing is readable or even recognizable. The solution to this behavior seems to be to set the “Override high DPI scaling behavior” setting to “Application”; the setting can be found by right clicking on the VirtualBox shortcut/executable > Properties > Compatibility > Override high DPI scaling behavior. I found the solution here.